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WebMar 27, 2013 · Redfield MM, Chen HH, Borlaug BA, Semigran MJ, Lee KL, Lewis G, et al. Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction. JAMA. 2013;309(12):1268-1277. eMethods. eTable 1. RELAX trial entry criteria. eTable 2. Biomarker reference ranges. eTable 3. WebAug 28, 2024 · In an editorial, NEJM Deputy Editor John Jarcho, MD, states the EMPEROR-Reduced trial proves DAPA-HF was “no fluke,” and the new findings strengthen the case for using SGLT2 inhibitors in HFrEF. “Guideline committees will now need to contend with the evidence,” he writes. This past May, the US Food and Drug Administration approved ... man city leipzig bbc
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