WebThakar found that when a molecule called ubiquitin modifies PCNA, it allows the protein to respond to stresses in replication—such as those brought on by chemotherapy. WebThe Moldovan lab of 2024: Michael O’Connor, Tanay Thakar, Lucian Moldovan, Claudia Nicolae, Emily Schleicher, Kristen Clements, and Anastasia Hale. The Moldovan lab of 2016: Patricia Yee, Tanay Thakar, Max Yakovlev, Soraya Bascoy, Adri Galvan, Jillian Weissenrieder, Lucian Moldovan, Claudia Nicolae, Michael O’Connor, Katherine Choe, and Kristen Clements.

Nathanial J. Tolman

WebView the profiles of professionals named "Tanay Thakar" on LinkedIn. There are 3 professionals named "Tanay Thakar", who use LinkedIn to exchange information, ideas, and opportunities. WebTanay Thakar Claudia M. Nicolae George-Lucian Moldovan Cyclin D1 is an essential regulator of the G1–S cell-cycle transition and is overexpressed in many cancers. Expression of cyclin D1 is... shop new arrivals

Articles in 2024 Nature Communications

WebOur business enterprise is owned by ' Mr. Tanay Thakar', under whose able leadership, we have been able to carve a niche in the industry. His leadership abilities and sharp business acumen are instrumental to our success. + Read More Nature of Business Exporter and Manufacturer Total Number of Employees 51 to 100 People Year of Establishment 1984 Nature Communications - PCNA is essential for DNA replication and cellular proliferation. Here, the authors reveal that PCNA ubiquitination protects stalled replication forks from DNA2-mediated ... See more As PCNA is essential for cell proliferation, previous studies investigating the role of PCNA ubiquitination in human cell lines relied on siRNA … See more As expected from the well-established role of PCNA in TLS, both 293T-K164R and RPE1-K164R cells were sensitive to DNA damaging agents that induce single-stranded DNA lesions, … See more In BRCA-deficient cells, nascent strand degradation by MRE11 occurs upon fork reversal25,26,41. We investigated if fork reversal is also required for nascent strand degradation in KR … See more To investigate if the abnormal replication fork characteristics described above are associated with defects in fork stability, we measured replication fork integrity in the presence of acute … See more WebTanay Thakar1, Wendy Leung2, Claudia M. Nicolae1, Kristen E. Clements1, Binghui Shen3, Anja-Katrin Bielinsky2& George-Lucian Moldovan1 Upon genotoxic stress, PCNA ubiquitination allows for... shop new balance สาขา