WebAbstract It is essential to study α-glucosidase enzyme (EC 3.2.1.20) inhibitors because of their physiological role as well as their clinical relevance. In previous research, a novel series of thio... WebThis design strategy considers the atomic structures of fibrils, employing rational and computational design techniques to derive a peptide sequence complementary to the growing fibril surface. ... These metrics were demonstrated to be predictive of successful designs in work by Chevalier et al. to create miniprotein binders .
MPG.eBooks - Staff View: Computational Peptide Science
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Computational Design of Miniprotein Binders. Methods Mol …
WebAug 3, 2024 · 62 designed binders completely from scratch without relying on known RBD-binding interactions 63 (Fig 1B). An advantage of the second approach is that the range of possibilities for design is 64 much larger, and so potentially a greater diversity of high-affinity binding modes can be 65 identified. WebJan 13, 2024 · A rational therapeutic strategy is urgently needed for combating SARS-CoV-2 infection. Viral infection initiates when the SARS-CoV-2 receptor-binding domain (RBD) binds to the ACE2 receptor, and thus, inhibiting RBD is a promising therapeutic for blocking viral entry. In this study, the structure of lead antiviral candidate binder (LCB1), which … WebMar 24, 2024 · For the unbound crystal structures of the FGFR2 miniprotein binder and the IL-7Rα miniprotein binder, the r.m.s.d. values were calculated over all the C α atoms … bpa and bps free thermal paper